We observed a significant decline in the use of varenicline after the passage of BBW. The BBW was not associated with decline in the use of bupropion. Passage of BBW may have a substantial impact on the utilization of certain medications. In 2009, the FDA required a black box warning (BBW) on bupropion and varenicline, the two commonly prescribed smoking cessation agents due to reports of adverse neuropsychiatric events. We investigated if there was a decline in use of bupropion and varenicline after the BBW by comparing the percent using these medications before and after BBW. We conducted a retrospective observational study using data from the Medical Expenditure Panel Survey from 2007 to 2014. The study sample consisted of adult smokers, who were advised by their physicians to quit smoking. We divided the time period into “pre-warning”, “post-warning: immediate”, and “post-warning: late.” Unadjusted analysis using chi-square tests and adjusted analyses using logistic regressions were conducted to evaluate the change in bupropion and varenicline use before and after the BBW. Secondary analyses using piecewise regression were also conducted. On an average, 49.04% of smokers were advised by their physicians to quit smoking. We observed a statistically significant decline in varenicline use from 22.1% in year 2007 to 9.23% in 2014 (p value < 0.001).
Oct 3, 2017 - Evansville Courier & Press Gary Thurby, left, and Heath Thurby are third- and fourth-generation tobacco farmers at Thurby Farms in Henderson County, Ky., Friday afternoon. They are hoping the tobacco crop this year makes up for the meager harvest of the past two years. DENNY SIMMONS / COURIER & PRESS ( continue reading ) Click one of the buttons below or search. Here you can find useful examples and description about searching the news archive. Read it carefully to get the best results. If you need more help, please contact us. Searching is case insensitive. Words music and mUSIC return the same results. Some of the common words like the, is, etc.
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